Progesterone inhibition in mid‐trimester termination of pregnancy: physiological and clinical effects
- 1 December 1987
- journal article
- research article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 94 (12), 1218-1222
- https://doi.org/10.1111/j.1471-0528.1987.tb02325.x
Abstract
A double-blind, placebo controlled clinical trial was conducted to assess the clinical and physiological effects of ''epostane'', a progesterone synthesis inhibitor, in mid-trimester prostaglandin termination of pregnancy. Mean peripheral progesterone levels had fallen by 74% after 72 h in the patients treated with epostane. The mean induction-abortion interval in the treatment group was 490 (SD 271) min, compared with 1432 (SD 640) min in the control group. Intrauterine pressure recording demonstrated increased sensitivity to prostaglandin E2 after epostane treatment but no change in oxytocin sensitivity. The clinical implications of facilitated induction of abortion are discussed.Keywords
This publication has 6 references indexed in Scilit:
- Local Inhibition of Progesterone Production in Human Chorio-Decidua by EpostaneHormone and Metabolic Research, 1986
- Inhibition of 3β-hydroxysteroid dehydrogenase (3β-HSD) activity in first- and second-trimester human pregnancy and the luteal phase using EpostaneFertility and Sterility, 1984
- Prolonged inhibition of placental and ovarian 3β-hydroxysteroid dehydrogenase during pregnancy and the luteal phase of the menstrual cycleJournal of Obstetrics and Gynaecology, 1984
- INHIBITION OF 3‐BETA‐HYDROXY STEROID DEHYDROGENASE ACTIVITY IN FIRST TRIMESTER HUMAN PREGNANCY WITH TRILOSTANE AND WIN 32729Clinical Endocrinology, 1983
- SINGLE EXTRA‐AMNIOTIC INJECTION OF PROSTAGLANDINS IN VISCOUS GEL TO INDUCE ABORTIONBJOG: An International Journal of Obstetrics and Gynaecology, 1976
- The effect of luteectomy-induced progesterone-withdrawal on the oxytocin and prostaglandin response of the first trimester pregnant human uterusProstaglandins, 1973