Transient Acute Depression Induced by High-Frequency Deep-Brain Stimulation
- 13 May 1999
- journal article
- case report
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 340 (19), 1476-1480
- https://doi.org/10.1056/nejm199905133401905
Abstract
Continuous high-frequency stimulation of the basal ganglia was recently introduced for the treatment of patients with advanced Parkinson's disease.1 This treatment seems to be most effective when the electrodes are placed in the subthalamic nuclei.2,3 Among the 20 patients treated successfully by bilateral subthalamic stimulation at our center, 1 woman had transient acute depression when high-frequency stimulation was delivered to the left substantia nigra, 2 mm below the site where stimulation alleviated the signs of Parkinson's disease. We describe here the results of detailed studies of the induction of major, reversible depression in this woman.Keywords
This publication has 18 references indexed in Scilit:
- Knowing Where and Getting There: A Human Navigation NetworkScience, 1998
- Subgenual prefrontal cortex abnormalities in mood disordersNature, 1997
- Poststroke DepressionStroke, 1995
- The Pharmacologic Treatment of DepressionThe New England Journal of Medicine, 1991
- Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleusThe Lancet, 1991
- Reversal of Experimental Parkinsonism by Lesions of the Subthalamic NucleusScience, 1990
- The primate mediodorsal (MD) nucleus and its projection to the frontal lobeJournal of Comparative Neurology, 1985
- Organization of the nigrothalamocortical system in the rhesus monkeyJournal of Comparative Neurology, 1985
- A Noninvasive Approach to Quantitative Functional Brain Mapping with H215O and Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1984
- MOOD DISORDERS IN STROKE PATIENTS: IMPORTANCE OF LOCATION OF LESIONBrain, 1984