A Noninvasive Approach to Quantitative Functional Brain Mapping with H215O and Positron Emission Tomography
- 1 September 1984
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 4 (3), 329-333
- https://doi.org/10.1038/jcbfm.1984.49
Abstract
Summary: Positron emission tomography (PET) was employed to examine time-dependent changes in blood-brain barrier (BBB) permeability to [68Ga]ethylenedi-aminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions.Keywords
This publication has 4 references indexed in Scilit:
- Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomographyJournal of Neurophysiology, 1984
- PETT VIJournal of Computer Assisted Tomography, 1982
- Performance Study of PETT VI, a Positron Computed Tomograph with 288 Cesium Fluoride DetectorsIEEE Transactions on Nuclear Science, 1982
- Engineering Aspects of PETT VIIEEE Transactions on Nuclear Science, 1982