Europium(III) DOTA-tetraamide Complexes as Redox-Active MRI Sensors
- 15 March 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (13), 5798-5800
- https://doi.org/10.1021/ja211601k
Abstract
PARACEST redox sensors containing the NAD+/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu3+ complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was “turned on” upon reduction with β-NADH. The CEST effect of the Eu3+ complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.Keywords
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