Modulation of Water Exchange in Europium(III) DOTA−Tetraamide Complexes via Electronic Substituent Effects
- 8 December 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 130 (1), 6-7
- https://doi.org/10.1021/ja076325y
Abstract
The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F ∼CO2tBu < CN ≪ H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.Keywords
This publication has 21 references indexed in Scilit:
- Paramagnetic lanthanide complexes as PARACEST agents for medical imagingChemical Society Reviews, 2006
- Selective Sensing of Zinc Ions with a PARACEST Contrast AgentAngewandte Chemie-International Edition, 2005
- Cyclen-Based Phenylboronate Ligands and Their Eu3+ Complexes for Sensing Glucose by MRIBioconjugate Chemistry, 2004
- Towards the Rational Design of Magnetic Resonance Imaging Contrast Agents: Isolation of the Two Coordination Isomers of Lanthanide DOTA‐Type ComplexesAngewandte Chemie-International Edition, 2003
- A Paramagnetic CEST Agent for Imaging Glucose by MRIJournal of the American Chemical Society, 2003
- The Water‐Exchange Rate in Neutral Heptadentate DO3A‐Like GdIII Complexes: Effect of the Basicity at the Macrocyclic Nitrogen SiteEuropean Journal of Inorganic Chemistry, 2003
- PARACEST Agents: Modulating MRI Contrast via Water Proton ExchangeAccounts of Chemical Research, 2003
- Controlling the variation of axial water exchange rates in macrocyclic lanthanide(iii) complexesElectronic supplementary information (ESI) available: experimental section. See http://www.rsc.org/suppdata/cc/b2/b202862j/Chemical Communications, 2002
- NMR, Relaxometric, and Structural Studies of the Hydration and Exchange Dynamics of Cationic Lanthanide Complexes of Macrocyclic Tetraamide LigandsJournal of the American Chemical Society, 1999
- Oxygen-17 NMR study of water exchange on gadolinium polyaminopolyacetates [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]- related to NMR imagingInorganic Chemistry, 1993