Detecting overlapping protein complexes in protein-protein interaction networks
Top Cited Papers
- 18 March 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Methods
- Vol. 9 (5), 471-472
- https://doi.org/10.1038/nmeth.1938
Abstract
ClusterONE detects overlapping protein complexes from large-scale weighted and unweighted protein-interaction networks. We introduce clustering with overlapping neighborhood expansion (ClusterONE), a method for detecting potentially overlapping protein complexes from protein-protein interaction data. ClusterONE-derived complexes for several yeast data sets showed better correspondence with reference complexes in the Munich Information Center for Protein Sequence (MIPS) catalog and complexes derived from the Saccharomyces Genome Database (SGD) than the results of seven popular methods. The results also showed a high extent of functional homogeneity.Keywords
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