BioGRID: a general repository for interaction datasets
Top Cited Papers
Open Access
- 1 January 2006
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 34 (90001), D535-D539
- https://doi.org/10.1093/nar/gkj109
Abstract
Access to unified datasets of protein and genetic interactions is critical for interrogation of gene/protein function and analysis of global network properties. BioGRID is a freely accessible database of physical and genetic interactions available at http://www.thebiogrid.org. BioGRID release version 2.0 includes >116 000 interactions from Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens. Over 30 000 interactions have recently been added from 5778 sources through exhaustive curation of the Saccharomyces cerevisiae primary literature. An internally hyper-linked web interface allows for rapid search and retrieval of interaction data. Full or user-defined datasets are freely downloadable as tab-delimited text files and PSI-MI XML. Pre-computed graphical layouts of interactions are available in a variety of file formats. User-customized graphs with embedded protein, gene and interaction attributes can be constructed with a visualization system called Osprey that is dynamically linked to the BioGRID.Keywords
This publication has 52 references indexed in Scilit:
- Conserved patterns of protein interaction in multiple speciesProceedings of the National Academy of Sciences of the United States of America, 2005
- IntAct: an open source molecular interaction databaseNucleic Acids Research, 2004
- The Database of Interacting Proteins: 2004 updateNucleic Acids Research, 2004
- A Protein Interaction Map of Drosophila melanogasterScience, 2003
- Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in HumansGenome Research, 2003
- Analyzing yeast protein–protein interaction data obtained from different sourcesNature Biotechnology, 2002
- Comparative assessment of large-scale data sets of protein–protein interactionsNature, 2002
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryNature, 2002
- Functional organization of the yeast proteome by systematic analysis of protein complexesNature, 2002
- A comprehensive two-hybrid analysis to explore the yeast protein interactomeProceedings of the National Academy of Sciences of the United States of America, 2001