211 G to A Variation of UDP-Glucuronosyl Transferase 1A1 Gene and Neonatal Breastfeeding Jaundice
- 1 February 2011
- journal article
- Published by Springer Science and Business Media LLC in Pediatric Research
- Vol. 69 (2), 170-174
- https://doi.org/10.1203/pdr.0b013e31820263d2
Abstract
Breastfeeding jaundice is a common problem in neonates who were exclusively breastfed, but its pathogenesis is still unclear. The uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphism was shown to contribute to the development of neonatal hyperbilirubinemia. We hypothesize that the variation of UGT1A1 gene may contribute to neonatal breastfeeding jaundice. We prospectively enrolled 688 near-term and term infants who were exclusively breastfed (BF group) or were supplemented by infant formula partially (SF group) before onset of hyperbilirubinemia. Genotyping of the promoter and exon1 of UGT1A1 was performed in all neonates. Neonates in BF group had a significantly higher maximal body weight loss ratio, peak bilirubin level, and a greater incidence of hyperbilirubinemia than those in SF group. Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG). This phenomenon was only seen in BF group but not in SF group when subset analysis was performed. This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice.Keywords
This publication has 30 references indexed in Scilit:
- Prolonged Unconjugated Hyperbiliriubinemia in Breast-fed Male Infants with a Mutation of Uridine Diphosphate-Glucuronosyl TransferaseThe Journal of Pediatrics, 2009
- Coexpression of Gene Polymorphisms Involved in Bilirubin Production and MetabolismPEDIATRICS, 2008
- Molecular genetics of unconjugated hyperbilirubinemia in TaiwaneseJournal of Biomedical Science, 2005
- Spectrum ofUGT1A1 mutations in Crigler-Najjar (CN) syndrome patients: identification of twelve novel alleles and genotype-phenotype correlationHuman Mutation, 2005
- Breastfeeding and the Use of Human MilkPEDIATRICS, 2005
- Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of GestationPediatrics, 2004
- Neonatal Jaundice and KernicterusPEDIATRICS, 2001
- The interaction between Gilbert's syndrome and G6PD deficiency influences bilirubin levelsBritish Journal of Haematology, 1999
- The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's SyndromeThe New England Journal of Medicine, 1995
- Comparison of Bilirubin Production in Japanese and Caucasian InfantsJournal of Pediatric Gastroenterology and Nutrition, 1988