The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome
- 2 November 1995
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 333 (18), 1171-1175
- https://doi.org/10.1056/nejm199511023331802
Abstract
People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal.Keywords
This publication has 37 references indexed in Scilit:
- Genetic heterogeneity of Crigler-Najjar syndrome type 1: A study of 14 casesHepatology, 1993
- The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locusPharmacogenetics, 1992
- Regulation of Inducible and Tissue-Specific Gene ExpressionScience, 1987
- Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cellsCell, 1983
- DNA sequences necessary for transcription of the rabbit β-globin gene in vivoNature, 1982
- Unconjugated Bilirubin and an Increased Proportion of Bilirubin Monoconjugates in the Bile of Patients with Gilbert's Syndrome and Crigler-Najjar DiseaseJCI Insight, 1977
- DOES GILBERT'S DISEASE EXIST?The Lancet, 1977
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- Inheritance of type 2 Crigler-Najjar hyperbilirubinaemiaGut, 1973
- Enhancement of Heme Catabolism by Caloric Restriction in ManScandinavian Journal of Clinical and Laboratory Investigation, 1972