Cucurbiturils: from synthesis to high-affinity binding and catalysis
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Open Access
- 15 October 2014
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 44 (2), 394-418
- https://doi.org/10.1039/c4cs00273c
Abstract
In the wide area of supramolecular chemistry, cucurbit[n]urils (CBn) present themselves as a young family of molecular containers, able to form stable complexes with various guests, including drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocarbons, and even high molecular weight guests such as proteins (e.g., human insulin). Since the discovery of the first CBn, CB6, the field has seen tremendous growth with respect to the synthesis of new homologues and derivatives, the discovery of record binding affinities of guest molecules in their hydrophobic cavity, and associated applications ranging from sensing to drug delivery. In this review, we discuss in detail the fundamental properties of CBn homologues and their cyclic derivatives with a focus on their synthesis and their applications in catalysis.Keywords
Funding Information
- German Academic Exchange Service (Fellowship KIA)
- Deutsche Forschungsgemeinschaft (NA-686/5)
- European Cooperation in Science and Technology (COST Action CM1005)
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