Platelets: a critical link between inflammation and microvascular dysfunction
- 1 March 2012
- journal article
- review article
- Published by Wiley in Journal Of Physiology-London
- Vol. 590 (5), 1023-1034
- https://doi.org/10.1113/jphysiol.2011.225417
Abstract
Inflammation is an underlying feature of a variety of human diseases. An important manifestation of this pathophysiological response is microvascular dysfunction, which includes the activation of vascular endothelial cells, and circulating leucocytes and platelets. While endothelial cells and leucocytes are widely accepted as critical players in the microvascular alterations induced by inflammation, recent attention has focused on the modulatory role of platelets, which act both as effector and target cells in inflamed microvessels. Evidence is presented to demonstrate the capacity for 'cross-talk' between platelets and other cells (endothelial cells, leucocytes) that contribute to an inflammatory response, and to illustrate the pathophysiological consequences of these interactions of platelets with other cells within the microvasculature.This publication has 103 references indexed in Scilit:
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