Chitosan-based scaffolds for bone tissue engineering
Top Cited Papers
- 5 March 2014
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry B
- Vol. 2 (21), 3161-3184
- https://doi.org/10.1039/c4tb00027g
Abstract
Bone defects requiring grafts to promote healing are frequently occurring and costly problems in health care. Chitosan, a biodegradable, naturally occurring polymer, has drawn considerable attention in recent years as a scaffolding material in tissue engineering and regenerative medicine. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of mineralized bone matrix. In this review, we discuss the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration. We present common methods for fabrication and characterization of chitosan scaffolds, and discuss the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitosan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration. Finally, we highlight recent advances in the development of chitosan-based scaffolds with enhanced bone regeneration capability.Keywords
This publication has 148 references indexed in Scilit:
- New sol‐gel bioactive glass and titania composites with enhanced physico‐chemical and biological propertiesJournal of Biomedical Materials Research Part A, 2013
- A Biomimetic Composite from Solution Self‐Assembly of Chitin Nanofibers in a Silk Fibroin MatrixAdvanced Materials, 2013
- Evaluation of three‐dimensional porous chitosan–alginate scaffolds in rat calvarial defects for bone regeneration applicationsJournal of Biomedical Materials Research Part A, 2013
- Effects of recombinant human bone morphogenic protein-2 and human bone marrow-derived stromal cells onin vivobone regeneration of chitosan-poly(ethylene oxide) hydrogelJournal of Biomedical Materials Research Part A, 2012
- Mineral coatings modulate β-TCP stability and enable growth factor binding and releaseActa Biomaterialia, 2012
- Bioceramics: From Bone Regeneration to Cancer NanomedicineAdvanced Materials, 2011
- Biomaterials that Regulate Growth Factor Activity via Bioinspired InteractionsAdvanced Functional Materials, 2011
- Chitosan-poly(butylene succinate) scaffolds and human bone marrow stromal cells induce bone repair in a mouse calvaria modelJournal of Tissue Engineering and Regenerative Medicine, 2011
- Pore Characteristics of Chitosan Scaffolds Studied by Electrochemical Impedance SpectroscopyTissue Engineering, Part C: Methods, 2010
- Effect of porosity and pore size on microstructures and mechanical properties of poly‐ε‐caprolactone‐ hydroxyapatite compositesJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2008