Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles
- 7 June 2021
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 19 (26), 5702-5724
- https://doi.org/10.1039/d1ob00838b
Abstract
The stereocontrolled formation of medium-sized carbocycles is a major goal in modern organic chemistry due to their widespread occurrence in natural products and pharmaceutically active ingredients. One approach consists in the use of cycloaddition reactions which notably results in high selectivities and atom-economy. To this end, cyclopropanes are ideal substrates since they can provide readily functionalized three- or five-carbon synthons. Herein we report advances made in cycloaddition reactions of cyclopropanes towards the synthesis of medium-sized carbocycles via transition metal catalysis or Lewis acid catalysis.Funding Information
- Fonds De La Recherche Scientifique - FNRS
- Fondation Louvain
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