Clinicopathologic and Diagnostic Imaging Characteristics of Systemic Aspergillosis in 30 Dogs
Open Access
- 4 July 2008
- journal article
- Published by Wiley in Journal of Veterinary Internal Medicine
- Vol. 22 (4), 851-859
- https://doi.org/10.1111/j.1939-1676.2008.0125.x
Abstract
Background: Systemic aspergillosis is a serious disease of dogs for which the clinical characteristics are poorly described. Objective: To describe the clinical and diagnostic imaging characteristics of dogs with systemic aspergillosis. Animals: Thirty dogs with systemic aspergillosis. Methods: Retrospective case review. Medical records were reviewed for signalment, clinical features, and results of clinicopathologic testing and diagnostic imaging. Diagnosis was confirmed by culture of Aspergillus terreus (n = 13), Aspergillus deflectus (n = 11), or other Aspergillus spp. (n = 6). Results: Compared with the background hospital population, German Shepherd dogs and female dogs were overrepresented (odds ratio [OR] 43, 95% confidence interval [CI] 20–91, P < .0001, and OR 2.9, 95% CI 1.2–6.7, P= .02), respectively, with 20 of the 30 dogs being German Shepherd dogs and 77% (23 of 30) of the dogs being female. The median age was 4.5 years (range 2–8 years). Anemia, leukocytosis, hyperglobulinemia, azotemia, hypercalcemia, and hypoalbuminemia were present in 8, 21, 12, 9, 8, and 6 dogs, respectively. Diskospondylitis, osteomyelitis and thoracic lymphadenomegaly were present in 16, 10, and 5 dogs, respectively. Sonographic findings were enlarged hypoechoic lymph nodes (n = 12), mottled and irregular kidneys with or without masses (n = 12), pyelectasia, and an aggregate of echogenic material in the renal pelvis (n = 9). Thirteen dogs were treated with antifungal drugs, with survival times ranging from 0 to 25 months after diagnosis. Conclusions and Clinical Importance: Systemic aspergillosis typically involves young to middle-age female German Shepherd dogs, and there are characteristic abdominal ultrasound findings with the disease process. Infection with A. deflectus was as common as A. terreus, and in rare cases, long-term survival was associated with antifungal therapy.Keywords
This publication has 24 references indexed in Scilit:
- Voriconazole Therapeutic Drug MonitoringAntimicrobial Agents and Chemotherapy, 2006
- Disseminated aspergillosis in two dogs in IsraelMycoses, 2006
- ECG of the MonthJournal of the American Veterinary Medical Association, 2001
- Long‐term survival of four dogs with disseminated Aspergillus terreus infection treated with itraconazoleAustralian Veterinary Journal, 1995
- Splenic Infarction in 16 Dogs: A Retrospective StudyJournal of Veterinary Internal Medicine, 1995
- Systemic aspergillosis in a dogVeterinary Record, 1993
- An immunohistochemical study of canine disseminated aspergillosisAustralian Veterinary Journal, 1991
- ULTRASONIC DETECTION OF SPLENIC NECROSIS IN THE DOGVeterinary Radiology, 1988
- The Pathology of Disseminated Aspergillus terreus Infection in DogsVeterinary Pathology, 1985
- Immunologic study of systemic aspergillosis in German Shepherd dogsVeterinary Immunology and Immunopathology, 1985