RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer
Open Access
- 26 November 2012
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 13 (12), 15755-15766
- https://doi.org/10.3390/ijms131215755
Abstract
The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the canonical and non-canonical nuclear receptor pathways, which in turn regulate various breast cancer cellular function, including cell proliferation, apoptosis and invasion. This information suggests that RORα is a potent tumor suppressor and a potential therapeutic target for breast cancer.This publication has 68 references indexed in Scilit:
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