Transcription factor RORα is critical for nuocyte development
Top Cited Papers
Open Access
- 22 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 13 (3), 229-236
- https://doi.org/10.1038/ni.2208
Abstract
Nuocytes are innate cells with critical roles during infection with parasitic worms. McKenzie and colleagues show that nuocytes differentiate from common lymphoid progenitors and require IL-7, IL-33, Notch and RORα for development. Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms.Keywords
This publication has 50 references indexed in Scilit:
- Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunityNature Immunology, 2011
- Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate LymphocytesImmunity, 2010
- A Large-Scale, Consortium-Based Genomewide Association Study of AsthmaThe New England Journal of Medicine, 2010
- Systemically dispersed innate IL-13–expressing cells in type 2 immunityProceedings of the National Academy of Sciences of the United States of America, 2010
- Distinguishing Mast Cell and Granulocyte Differentiation at the Single-Cell LevelCell Stem Cell, 2010
- Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityNature, 2010
- Fate Mapping Reveals Separate Origins of T Cells and Myeloid Lineages in the ThymusImmunity, 2010
- T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγImmunity, 2008
- Launching the T-cell-lineage developmental programmeNature Reviews Immunology, 2008
- The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotypeImmunity, 1994