Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women
Open Access
- 14 March 2013
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 207 (12), 1798-1806
- https://doi.org/10.1093/infdis/jit093
Abstract
Background. Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)–associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy. Methods. To describe clinical and virologic manifestations of primary EBV infection among infants born to HIV-infected women, specimens were utilized from a cohort study conducted in Nairobi, Kenya. HIV and EBV viral loads were measured serially in plasma. EBV serology was performed on EBV DNA–negative infants. Monthly clinical examinations were performed by pediatricians. Results. The probability of EBV infection by 1 year of age was .78 (95% CI, .67–.88) in HIV-infected and .49 (95% CI, .35–.65) in HIV-uninfected infants (P < .0001). At 2 years, probability of EBV infection was .96 (95% CI, .89–.99) in HIV-infected infants. Peak EBV loads were higher in HIV-infected versus HIV-uninfected infants (median 2.6 vs 2.1 log10 copies/mL; P < .0001). The majority of HIV-infected infants had detectable EBV DNA for >3 months (79%). Primary EBV infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and hospitalization in HIV-infected infants; conjunctivitis and rhinorrhea in HIV-uninfected infants. Conclusions. EBV infection occurs early in infants born to HIV-infected women. HIV infection was associated with more frequent and higher quantity EBV DNA detection.Keywords
This publication has 50 references indexed in Scilit:
- Early Age at Time of Primary Epstein–Barr Virus Infection Results in Poorly Controlled Viral Infection in Infants From Western Kenya: Clues to the Etiology of Endemic Burkitt LymphomaThe Journal of Infectious Diseases, 2012
- Primary gamma-herpesviral infection in Zambian childrenBMC Infectious Diseases, 2010
- Strategic approaches to decrease breast milk transmission of HIV-1: the importance of small things.The Journal of Infectious Diseases, 2009
- Role of Uncontrolled HIV RNA Level and Immunodeficiency in the Occurrence of Malignancy in HIV‐Infected Patients during the Combination Antiretroviral Therapy Era: Agence Nationale de Recherche sur le Sida (ANRS) CO3 Aquitaine CohortClinical Infectious Diseases, 2009
- Comparison of human herpesvirus 8 and Epstein–Barr virus seropositivity among children in areas endemic and non‐endemic for Kaposi's sarcomaJournal of Medical Virology, 2003
- Characteristics of Hodgkin's Lymphoma after Infectious MononucleosisThe New England Journal of Medicine, 2003
- Natural History of Primary Epstein‐Barr Virus Infection in Children of Mothers Infected with Human Immunodeficiency Virus Type 1The Journal of Infectious Diseases, 1999
- Natural History of Epstein‐Barr Virus Infection in a Prospective Pediatric Cohort Born to Human Immunodeficiency Virus‐Infected MothersThe Journal of Infectious Diseases, 1998
- EPSTEIN-BARR VIRUS ANTIBODY LEVELS IN CHILDREN FROM THE WEST NILE DISTRICT OF UGANDA: Report of a Field StudyThe Lancet, 1972
- A sarcoma involving the jaws in african childrenBritish Journal of Surgery, 1958