Mast Cells: A Pivotal Role in Pulmonary Fibrosis
- 1 April 2013
- journal article
- research article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 32 (4), 206-218
- https://doi.org/10.1089/dna.2013.2005
Abstract
Pulmonary fibrosis is characterized by an inflammatory response that includes macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study was to evaluate whether mast cells play a role in initiating pulmonary fibrosis. Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient WBB6F1-W/Wv (MCD) mice and their congenic controls (WBB6F1-+/+). Mast cell deficiency protected against bleomycin-induced pulmonary fibrosis, but protection was reversed with the re-introduction of mast cells to the lungs of MCD mice. Two mast cell mediators were identified as fibrogenic: histamine and renin, via angiotensin (ANG II). Both human and rat lung fibroblasts express the histamine H1 and ANG II AT1 receptor subtypes and when activated, they promote proliferation, transforming growth factor β1 secretion, and collagen synthesis. Mast cells appear to be critical to pulmonary fibrosis. Therapeutic blockade of mast cell degranulation and/or histamine and ANG II receptors should attenuate pulmonary fibrosis.Keywords
This publication has 49 references indexed in Scilit:
- Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction modelAmerican Journal of Physiology-Renal Physiology, 2012
- Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung AlveolarizationCell, 2011
- Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trialsThe Lancet, 2011
- An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and ManagementAmerican Journal of Respiratory and Critical Care Medicine, 2011
- Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1+ smokers with early emphysemaJournal of Leukocyte Biology, 2009
- Idiopathic pulmonary fibrosisOrphanet Journal of Rare Diseases, 2008
- Mast cell renin and a local renin–angiotensin system in the airway: Role in bronchoconstrictionProceedings of the National Academy of Sciences of the United States of America, 2008
- TGF-β1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathwaysAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
- A pathologistʼs approach to interstitial lung diseaseCurrent Opinion in Pulmonary Medicine, 1996
- Effect of histamine on proliferation of normal human adult lung fibroblasts.Thorax, 1988