The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Open Access
- 10 December 2012
- journal article
- review article
- Published by Bioscientifica in Journal of Molecular Endocrinology
- Vol. 50 (1), R11-R19
- https://doi.org/10.1530/jme-12-0203
Abstract
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insultsin vitroand also improves cardiovascular disease as well as Alzheimer's diseasein vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.Keywords
This publication has 51 references indexed in Scilit:
- Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptideClinical and Experimental Nephrology, 2004
- N-Formylated humanin activates both formyl peptide receptor-like 1 and 2Biochemical and Biophysical Research Communications, 2004
- Humanin, a Newly Identified Neuroprotective Factor, Uses the G Protein-Coupled Formylpeptide Receptor-Like-1 as a Functional ReceptorPublished by The American Association of Immunologists ,2004
- Effect of humanin analogues on experimentally induced impairment of spatial memory in ratsJournal of Peptide Science, 2004
- Humanin rescues cortical neurons from prion-peptide-induced apoptosisMolecular and Cellular Neuroscience, 2004
- Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosisProceedings of the National Academy of Sciences of the United States of America, 2003
- Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ1–40Peptides, 2003
- Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes.Molecular and Cellular Biochemistry, 2003
- Detection, localization, and sequence analyses of mitochondrial regulatory region RNAs in several mammalian species.The Journal of Biochemistry, 1998
- Sequence and organization of the human mitochondrial genomeNature, 1981