Sequence and organization of the human mitochondrial genome
- 9 April 1981
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 290 (5806), 457-465
- https://doi.org/10.1038/290457a0
Abstract
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.Keywords
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