Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application
Open Access
- 6 December 2019
- journal article
- review article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2019, 1-16
- https://doi.org/10.1155/2019/3295756
Abstract
Platelet-rich fibrin (PRF) is an autologous platelet concentrate that consists of cytokines, platelets, leukocytes, and circulating stem cells. It has been considered to be effective in bone regeneration and is mainly used for oral and maxillofacial bone. Although currently the use of PRF is thought to support alveolar ridge preservation, there is a lack of evidence regarding the application of PRF in osteogenesis. In this paper, we will provide examples of PRF application, and we will also summarize different measures to improve the properties of PRF for achieving better osteogenesis. The effect of PRF as a bone graft material on osteogenesis based on laboratory investigations, animal tests, and clinical evaluations is first reviewed here. In vitro, PRF was able to stimulate cell proliferation, differentiation, migration, mineralization, and osteogenesis-related gene expression. Preclinical and clinical trials suggested that PRF alone may have a limited effect. To enlighten researchers, modified PRF graft materials are further reviewed, including PRF combined with other bone graft materials, PRF combined with drugs, and a new-type PRF. Finally, we will summarize the common shortcomings in the application of PRF that probably lead to application failure. Future scientists should avoid or solve these problems to achieve better regeneration.This publication has 120 references indexed in Scilit:
- In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrateBritish Journal of Oral and Maxillofacial Surgery, 2013
- Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone AugmentationBioMed Research International, 2013
- Evaluation of efficacy of autologous platelet-rich fibrin with demineralized-freeze dried bone allograft in the treatment of periodontal intrabony defectsJournal of Indian Society of Periodontology, 2013
- Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesionJournal of Conservative Dentistry, 2013
- Comparison of platelet rich fibrin and collagen as osteoblast‐seeded scaffolds for bone tissue engineering applicationsClinical Oral Implants Research, 2011
- Successful Periodontal Ligament Regeneration by Periodontal Progenitor Preseeding on Natural Tooth Root SurfacesStem Cells and Development, 2011
- Three‐Dimensional Architecture and Cell Composition of a Choukroun's Platelet‐Rich Fibrin Clot and MembraneThe Journal of Periodontology, 2010
- Differential Effect of Scaffold Shape on Dentin RegenerationAnnals of Biomedical Engineering, 2010
- Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healingOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2006
- Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates?Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2006