Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesion
Open Access
- 1 January 2013
- journal article
- case report
- Published by Medknow in Journal of Conservative Dentistry
- Vol. 16 (3), 261-4
- https://doi.org/10.4103/0972-0707.111329
Abstract
Periapical inflammatory lesion is the local response of bone around the apex of tooth that develops after the necrosis of the pulp tissue or extensive periodontal disease. The final outcome of the nature of wound healing after endodontic surgery can be repair or regeneration depending on the nature of the wound; the availability of progenitor cells; signaling molecules; and micro-environmental cues such as adhesion molecules, extracellular matrix, and associated non-collagenous protein molecules. The purpose of this case report is to add knowledge to the existing literature about the combined use of graft material [platelet rich fibrin (PRF) and hydroxyapatite (HA)] and barrier membrane in the treatment of large periapical lesion.A periapical endodontic surgery was performed on a 45 year old male patient with a swelling in the upper front teeth region and a large bony defect radiologically. The surgical defect was filled with a combination of PRF and HA bone graft crystals. The defect was covered by PRF membrane and sutured.Clinical examination revealed uneventful wound healing. Radiologically the HA crystals have been completely replaced by new bone at the end of 2 years.On the basis of the results obtained in our case report, we hypothesize that the use of PRF in conjunction with HA crystals might have accelerated the resorption of the graft crystals and would have induced the rapid rate of bone formation.Keywords
This publication has 25 references indexed in Scilit:
- Comparative Evaluation of Autologous Platelet‐Rich Fibrin and Platelet‐Rich Plasma in the Treatment of 3‐Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical TrialThe Journal of Periodontology, 2012
- Does periodontal tissue regeneration really work?Periodontology 2000, 2009
- Platelet-rich fibrin: evolution of a second-generation platelet concentrate.Indian Journal of Dental Research, 2008
- Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healingOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2006
- Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates?Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2006
- Treatment of Periapical Inflammatory Lesion with the Combination of Platelet-Rich Plasma and Tricalcium Phosphate: A Case ReportJournal of Endodontics, 2004
- Interactions between Bcl-2 and the IGF system control apoptosis in the developing mouse brainDevelopmental Brain Research, 1999
- Potentiation of transforming growth factor (TGF-β1) by natural coral and fibrin in a rabbit cranioplasty modelCalcified Tissue International, 1994
- Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*Endocrinology, 1988
- Hydroxylapatite as an Alloplastic Graft in the Treatment of Human Periodontal Osseous DefectsThe Journal of Periodontology, 1985