The Anion Gap

Abstract

The anion gap can be readily calculated from routine laboratory data, and although it has its widest application in the diagnosis of various forms of metabolic acidosis,^{1 , 2} it may sometimes provide an important clue to the diagnosis of disorders such as multiple myeloma^{3 4 5} or bromide intoxication.⁶ However, the concept of the anion gap is often misunderstood and misapplied. The purpose of this communication is to discuss in some detail the concept of the anion gap, the implications of abnormalities of the anion gap and, finally, its application to the differential diagnosis of metabolic acidosis.Concept of the Anion GapThe . . .