Rewiring cellular networks by members of the Flaviviridae family
- 12 February 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 16 (3), 125-142
- https://doi.org/10.1038/nrmicro.2017.170
Abstract
Members of the Flaviviridae virus family comprise a large group of enveloped viruses with a single-strand RNA genome of positive polarity. Several genera belong to this family, including the Hepacivirus genus, of which hepatitis C virus (HCV) is the prototype member, and the Flavivirus genus, which contains both dengue virus and Zika virus. Viruses of these genera differ in many respects, such as the mode of transmission or the course of infection, which is either predominantly persistent in the case of HCV or acutely self-limiting in the case of flaviviruses. Although the fundamental replication strategy of Flaviviridae members is similar, during the past few years, important differences have been discovered, including the way in which these viruses exploit cellular resources to facilitate viral propagation. These differences might be responsible, at least in part, for the various biological properties of these viruses, thus offering the possibility to learn from comparisons. In this Review, we discuss the current understanding of how Flaviviridae viruses manipulate and usurp cellular pathways in infected cells. Specifically, we focus on comparing strategies employed by flaviviruses with those employed by hepaciviruses, and we discuss the importance of these interactions in the context of viral replication and antiviral therapies.Keywords
This publication has 175 references indexed in Scilit:
- Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virusProceedings of the National Academy of Sciences of the United States of America, 2011
- Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication CompartmentCell Host & Microbe, 2011
- Dengue Virus-Induced Autophagy Regulates Lipid MetabolismCell Host & Microbe, 2010
- Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infectionVirology, 2010
- A genome-wide genetic screen for host factors required for hepatitis C virus propagationProceedings of the National Academy of Sciences of the United States of America, 2009
- The autophagy machinery is required to initiate hepatitis C virus replicationProceedings of the National Academy of Sciences of the United States of America, 2009
- Discovery of insect and human dengue virus host factorsNature, 2009
- Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly SitesCell Host & Microbe, 2009
- RNA interference screen for human genes associated with West Nile virus infectionNature, 2008
- XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription FactorCell, 2001