Intermediate Mutation Frequencies Favor Evolution of Multidrug Resistance in Escherichia coli
Open Access
- 1 October 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 171 (2), 825-827
- https://doi.org/10.1534/genetics.105.045526
Abstract
In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies.Keywords
This publication has 20 references indexed in Scilit:
- Lethal mutagenesis of HIVVirus Research, 2005
- Hypermutable Haemophilus influenzae with mutations in mutS are found in cystic fibrosis sputumMicrobiology, 2004
- Dynamics of Long-Term Colonization of Respiratory Tract byHaemophilus influenzaein Cystic Fibrosis Patients Shows a Marked Increase in Hypermutable StrainsJournal of Clinical Microbiology, 2004
- Hypermutation as a Factor Contributing to the Acquisition of Antimicrobial ResistanceClinical Infectious Diseases, 2003
- Frequency of Mutation to Rifampin Resistance in Streptococcus pneumoniae Clinical Strains: hexA and hexB Polymorphisms Do Not Account for HypermutationAntimicrobial Agents and Chemotherapy, 2003
- Mutator Bacteria as a Risk Factor in Treatment of Infectious DiseasesAntimicrobial Agents and Chemotherapy, 2002
- High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli IsolatesJournal of Bacteriology, 2002
- Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutScience, 2001
- Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliScience, 1997
- Immune surveillance in colorectal carcinomaNature Genetics, 1995