Mutator Bacteria as a Risk Factor in Treatment of Infectious Diseases
Open Access
- 1 March 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (3), 863-865
- https://doi.org/10.1128/aac.46.3.863-865.2002
Abstract
We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.Keywords
This publication has 17 references indexed in Scilit:
- High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli IsolatesJournal of Bacteriology, 2002
- Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutScience, 2001
- Mutator Natural Escherichia coli Isolates Have an Unusual Virulence PhenotypeInfection and Immunity, 2001
- High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung InfectionScience, 2000
- Effects of Environment on Compensatory Mutations to Ameliorate Costs of Antibiotic ResistanceScience, 2000
- A conspicuous adaptability to antibiotics in theEscherichia colimutator strain,dnaQ49FEMS Microbiology Letters, 1999
- To be a mutator, or how pathogenic and commensal bacteria can evolve rapidlyTrends in Microbiology, 1997
- Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliScience, 1997
- The Complete Genome Sequence of Escherichia coli K-12Science, 1997
- High Mutation Frequencies Among Escherichia coli and Salmonella PathogensScience, 1996