Dynamic Contrast Enhanced, Pelvic Phased Array Magnetic Resonance Imaging of Localized Prostate Cancer for Predicting Tumor Volume: Correlation With Radical Prostatectomy Findings
Top Cited Papers
- 31 December 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 176 (6), 2432-2437
- https://doi.org/10.1016/j.juro.2006.08.007
Abstract
We assessed the value of pelvic phased array dynamic contrast enhanced magnetic resonance imaging for predicting the intraprostatic location and volume of clinically localized prostate cancers. Suspicious areas on prospective pre-biopsy magnetic resonance imaging in 24 patients were assigned a magnetic resonance imaging malignancy score and located with respect to anatomical features, gland side, and transition and peripheral zone boundaries. The largest surface area and volume were measured. These magnetic resonance imaging findings were compared with radical prostatectomy specimen histopathology findings. Histopathology maps detected 56 separate cancer foci. The largest tumor focus was located in the peripheral zone in 14 patients and in the transition zone in 10. T1-weighted dynamic contrast enhanced magnetic resonance imaging identified 30 of the 39 tumor foci greater than 0.2 cc and 27 of the 30 greater than 0.5 cc. T2-weighted sequences were suspicious in 22 of 30 foci greater than 0.2 cc that were identified by T1-weighted dynamic contrast enhanced magnetic resonance imaging sequences. Sensitivity, specificity, and positive and negative predictive values for cancer detection by magnetic resonance imaging were 77%, 91%, 86% and 85% for foci greater than 0.2 cc, and 90%, 88%, 77% and 95% for foci greater than 0.5 cc, respectively. Median focus volume was 1.37 cc (range 0.338 to 6.32) for foci greater than 0.2 cc detected by magnetic resonance imaging in the peripheral zone and 0.503 cc (range 0.337 to 1.345) for those not detected by magnetic resonance imaging (p <0.05). Corresponding median values for transition zone foci were 2.54 (range 0.75 to 16.87) and 0.435 (range 0.26 to 0.58). Pre-biopsy pelvic phased array dynamic contrast enhanced magnetic resonance imaging is an accurate technique for detecting and quantifying intracapsular transition or peripheral zone tumor foci greater than 0.2 cc. It has promising implications for cancer detection, prognosis and treatment.Keywords
This publication has 20 references indexed in Scilit:
- COMPARISON OF ENDORECTAL MAGNETIC RESONANCE IMAGING, GUIDED PROSTATE BIOPSY AND DIGITAL RECTAL EXAMINATION IN THE PREOPERATIVE ANATOMICAL LOCALIZATION OF PROSTATE CANCERJournal of Urology, 2005
- IS TUMOR VOLUME AN INDEPENDENT PROGNOSTIC FACTOR IN CLINICALLY LOCALIZED PROSTATE CANCER?Journal of Urology, 2004
- Endorectal MRI for prediction of tumor site, tumor size, and local extension of prostate cancerUrology, 2004
- Characterization of time-enhancement curves of benign and malignant prostate tissue at dynamic MR imagingEuropean Radiology, 2003
- Extended Peripheral Zone Biopsy Schemes Increase Cancer Detection Rates and Minimize Variance in Prostate Specific Antigen and Age Related Cancer Rates: Results of a Community Multi-Practice StudyJournal of Urology, 2003
- Prostate Cancer Tumor Volume: Measurement with Endorectal MR and MR Spectroscopic ImagingRadiology, 2002
- Endorectal Color Doppler Sonography and Endorectal MR Imaging Features of Nonpalpable Prostate CancerAmerican Journal of Roentgenology, 2000
- PROSTATE CANCER IS HIGHLY PREDICTABLE: A PROGNOSTIC EQUATION BASED ON ALL MORPHOLOGICAL VARIABLES IN RADICAL PROSTATECTOMY SPECIMENSJournal of Urology, 2000
- Histologic differentiation, cancer volume, and pelvic lymph node metastasis in adenocarcinoma of the prostateCancer, 1990
- Comparison of Magnetic Resonance Imaging and Ultrasonography in Staging Early Prostate CancerThe New England Journal of Medicine, 1990