Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet
Open Access
- 9 June 2021
- Vol. 13 (6), 1999
- https://doi.org/10.3390/nu13061999
Abstract
Non-alcoholic fatty liver disease (NAFLD) is currently estimated as the most prevalent chronic liver disease in all age groups. An increasing body of evidence obtained in experimental and clinical data indicates that oxidative stress is the most important pathogenic factor in the development of NAFLD. The study aimed to investigate the impact of α-lipoic acid (LA), widely used as an antioxidant, on the effects of a hypercaloric choline-deficient diet. Male Wistar rats were divided into three groups: control diet (C); hypercaloric choline-deficient diet (HCCD), and hypercaloric choline-deficient diet with α-lipoic acid (HCCD+LA). Supplementation of HCCD with LA for eight weeks led to a decrease in visceral adipose tissue/body weight ratio, the activity of liver glutathione peroxidase and paraoxonase-1, plasma, and liver total antioxidant activity, as well as an increase in liver/body weight ratio, liver total lipid and triglyceride content, and liver transaminase activities compared to the HCCD group without LA. In conclusion, our study shows that α-lipoic acid detains obesity development but exacerbates the severity of diet-induced oxidative stress and lipid accumulation in the liver of male Wistar rats fed a hypercaloric choline-deficient diet.Keywords
Funding Information
- Ministry of Science and Higher Education of the Russian Federation (0529-2019-0058)
This publication has 60 references indexed in Scilit:
- Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patientsHepatology, 2012
- α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat dietNutrition Research and Practice, 2012
- Fish oil improves lipid metabolism and ameliorates inflammation in patients with metabolic syndrome: Impact of nonalcoholic fatty liver diseasePharmaceutical Biology, 2011
- Measurement of serum paraoxonase-1 activity in the evaluation of liver functionWorld Journal of Gastroenterology, 2009
- Pro-oxidant actions of α-lipoic acid and dihydrolipoic acidMedical Hypotheses, 2006
- Hepatic histology in obese patients undergoing bariatric surgeryJournal of Hepatology, 2006
- Defining high-fat-diet rat models: metabolic and molecular effects of different fat typesJournal of Molecular Endocrinology, 2006
- Differential effect of antioxidant treatment on plasma and tissue paraoxonase activity in hyperleptinemic ratsPharmacological Research, 2005
- CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitisJCI Insight, 2000
- The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygenBiochemical and Biophysical Research Communications, 1972