Lewis Acid‐Catalyzed Intramolecular [3+2] Cycloaddition of Cyclopropane 1,1‐Diesters with Alkynes for the Synthesis of Cyclopenta[c]chromene Skeletons
- 5 April 2012
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 7 (7), 1538-1541
- https://doi.org/10.1002/asia.201200104
Abstract
An efficient method to construct cyclopenta[c]chromene skeletons by Lewis acid-catalyzed intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with alkynes is presented. Two new fused cycles can be formed in one step in moderate to excellent yields (up to 94 %), and the products can be converted into bioactive barbituric acid derivatives (1) under simple reaction conditions.Keywords
Funding Information
- National Science Foundation NSF (21072080)
- Fundamental Research Funds for the Central Universities (lzujbky-2011-151, lzujbky-2010-k09)
- National Basic Research Program of China (2010CB833203)
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