C−H Bond Functionalization via Hydride Transfer: Synthesis of Dihydrobenzopyrans from ortho-Vinylaryl Akyl Ethers
- 23 June 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (14), 2972-2975
- https://doi.org/10.1021/ol900915p
Abstract
The hydride transfer initiated cyclization (“HT-cyclization”) of aryl alkyl ethers, which leads to direct coupling of sp3 C−H bonds and activated alkenes, is reported. Readily available salicylaldehyde derived ethers are converted in one step to dihydrobenzopyrans, an important class of heteroarenes frequently found in biologically active compounds. This process has not been previously reported, in contrast to known HT-cyclizations of the corresponding tert-amines (“tert-amino effect” reactions).Keywords
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