SARS-CoV-2 RNA concentrations in primary municipal sewage sludge as a leading indicator of COVID-19 outbreak dynamics
Open Access
- 22 May 2020
- preprint content
- other
- Published by Cold Spring Harbor Laboratory
Abstract
We report a time course of SARS-CoV-2 RNA concentrations in primary sewage sludge during the Spring COVID-19 outbreak in a northeastern U.S. metropolitan area. SARS-CoV-2 RNA was detected in all environmental samples, and when adjusted for the time lag, the virus RNA concentrations tracked the COVID-19 epidemiological curve. SARS-CoV-2 RNA concentrations were a leading indicator of community infection ahead of compiled COVID-19 testing data and local hospital admissions. Decisions to implement or relax public health measures and restrictions require timely information on outbreak dynamics in a community.Keywords
This publication has 13 references indexed in Scilit:
- Prevalence of Asymptomatic SARS-CoV-2 InfectionAnnals of Internal Medicine, 2020
- First con firmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the communityScience of The Total Environment, 2020
- Fecal specimen diagnosis 2019 novel coronavirus-infected pneumoniaJournal of Medical Virology, 2020
- An interactive web-based dashboard to track COVID-19 in real timeThe Lancet Infectious Diseases, 2020
- Evaluation of lockdown impact on SARS-CoV-2 dynamics through viral genome quantification in Paris wastewatersPublished by Cold Spring Harbor Laboratory ,2020
- SARS-CoV-2 titers in wastewater are higher than expected from clinically confirmed casesPublished by Cold Spring Harbor Laboratory ,2020
- Monitoring the COVID-19 epidemic in the context of widespread local transmissionThe Lancet Respiratory Medicine, 2020
- Presence of SARS-Coronavirus-2 in sewagePublished by Cold Spring Harbor Laboratory ,2020
- Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral sheddingNature Medicine, 2020
- Identification of Viral Pathogen Diversity in Sewage Sludge by Metagenome AnalysisEnvironmental Science & Technology, 2013