Mechanisms of Action of Conjugated Linoleic Acid: Evidence and Speculation
- 1 January 2000
- journal article
- Published by Wiley in Proceedings of the Society for Experimental Biology and Medicine
- Vol. 223 (1), 8-13
- https://doi.org/10.1046/j.1525-1373.2000.22302.x
Abstract
Conjugated linoleic acid (CLA) has been shown to inhibit carcinogenesis and atherosclerosis, enhance immunologic function while protecting against the cata- bolic effects of immune stimulation, affect body composition change (reducing body fat gain while enhancing lean body mass gain), and stimulate the growth of young rats. We discuss possible biochemical mechanisms that underlie these physiological effects. We emphasize the importance of considering the effects, both individually and combined, of the two CLA isomers (cis-9, trans-11 CLA and trans-10, cis-12 CLA) that have been shown to exhibit biological activity and which appear to exert their effects via different biochemical mechanisms. (P.S.E.B.M. 2000, Vol 223)Keywords
This publication has 37 references indexed in Scilit:
- Improved separation of conjugated fatty acid methyl esters by silver ion‐high‐performance liquid chromatographyLipids, 1999
- Silver‐ion high‐performance liquid chromatographic separation and identification of conjugated linoleic acid isomersLipids, 1998
- Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acidsLipids, 1997
- Effect of conjugated linoleic acid on body composition in miceLipids, 1997
- Cows' Milk Fat Components as Potential Anticarcinogenic AgentsJournal of Nutrition, 1997
- Conjugated linoleic acid and atherosclerosis in rabbitsAtherosclerosis, 1994
- Feeding Conjugated Linoleic Acid to Animals Partially Overcomes Catabolic Responses Due to Endotoxin InjectionBiochemical and Biophysical Research Communications, 1994
- Immune Modulation by Altered Nutrient Metabolism: Nutritional Control of Immune-Induced Growth DepressionPoultry Science, 1993
- Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogensJournal of Food Composition and Analysis, 1992
- Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acidCarcinogenesis: Integrative Cancer Research, 1987