Effect of conjugated linoleic acid on body composition in mice
- 1 August 1997
- Vol. 32 (8), 853-858
- https://doi.org/10.1007/s11745-997-0109-x
Abstract
The effects of conjugated linoleic acid (CLA) on body composition were investigated. ICR mice were fed a control diet containing 5.5% corn oil or a CLA-supplemented diet (5.0% corn oil plus 0.5% CLA). Mice fed CLA-supplemented diet exhibited 57% and 60% lower body fat and 5% and 14% increased lean body mass relative to controls (P−4 M) significantly reduced heparin-releasable lipoprotein lipase activity (−66%) and the intracellular concentrations of triacylglyceride (−8%) and glycerol (−15%), but significantly increased free glycerol in the culture medium (+22%) compared to control (P<0.05). The effects of CLA on body composition appear to be due in part to reduced fat deposition and increased lipolysis in adipocytes, possibly coupled with enhanced fatty acid oxidation in both muscle cells and adipocytes.Keywords
This publication has 35 references indexed in Scilit:
- Detection of conjugated diene isomers of linoleic acid in liver lipids of rats fed a choline-devoid diet indicates that the diet does not cause lipoperoxidationThe Journal of Nutritional Biochemistry, 1995
- Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.JCI Insight, 1995
- Conjugated linoleic acid and atherosclerosis in rabbitsAtherosclerosis, 1994
- Feeding Conjugated Linoleic Acid to Animals Partially Overcomes Catabolic Responses Due to Endotoxin InjectionBiochemical and Biophysical Research Communications, 1994
- Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin ResistanceScience, 1993
- Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogensJournal of Food Composition and Analysis, 1992
- Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.JCI Insight, 1989
- The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear CellsThe New England Journal of Medicine, 1989
- Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheesesJournal of Agricultural and Food Chemistry, 1989
- Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice.The Journal of Experimental Medicine, 1985