A mini‐review: Cell response to microscale, nanoscale, and hierarchical patterning of surface structure
- 28 March 2014
- journal article
- review article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 102 (7), 1580-1594
- https://doi.org/10.1002/jbm.b.33158
Abstract
Cellular behavior can be influenced by the chemical and physical surface characteristics of biomedical substrates. To understand the relationships between various topographical surface patterns and cellular activities, various types of pattern models have been developed and examined in a range of sizes (microscale, nanoscale, and hierarchical structures consisting of both) and shapes (pillar, hole, groove, grate, grid, and island). Here, we review fabrication methods for obtaining physically patterned microscale and nanoscale surfaces, and discuss the relationships between cellular responses and physically patterned surfaces, which could be applied to various biomedical scaffolds used in tissue engineering applications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1580–1594, 2014.Keywords
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