Pharmacokinetic and biodistribution study following systemic administration of Fospeg® – a Pegylated liposomal mTHPC formulation in a murine model
- 23 December 2013
- journal article
- research article
- Published by Wiley in Journal of Biophotonics
- Vol. 8 (1-2), 142-152
- https://doi.org/10.1002/jbio.201300133
Abstract
Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5–18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance imaging exhibit good correlation with chemical extraction. Our results have shown that optical imaging provides the potential for fluorophore quantification in biological tissues. (© 2013 WILEY-VCH Verlag GmbH &Co. KGaA, Weinheim)Keywords
This publication has 34 references indexed in Scilit:
- Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivoInternational Journal of Nanomedicine, 2013
- Comparative characterization of the cellular uptake and photodynamic efficiency of Foscan® and Fospeg in a human prostate cancer cell linePhotodiagnosis and Photodynamic Therapy, 2012
- Fluorescence localization and kinetics of mTHPC and liposomal formulations of mTHPC in the window‐chamber tumor modelLasers in Surgery and Medicine, 2011
- Drug quantification in turbid media by fluorescence imaging combined with light-absorption correction using white Monte Carlo simulationsJournal of Biomedical Optics, 2011
- Photodynamic therapy: superficial and interstitial illuminationJournal of Biomedical Optics, 2010
- Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applicationsJournal of Photochemistry and Photobiology B: Biology, 2010
- Unusual Photoinduced Response of mTHPC Liposomal Formulation (Foslip)Photochemistry and Photobiology, 2009
- Correlation between in vivo pharmacokinetics, intratumoral distribution and photodynamic efficiency of liposomal mTHPCJournal of Controlled Release, 2009
- Photodynamic therapy with intratumoral administration of Lipid‐Based mTHPC in a model of breast cancer recurrenceLasers in Surgery and Medicine, 2008
- The pharmacokinetic behavior of the photosensitizer meso-tetra-hydroxyphenyl-chlorin in mice and menCancer Chemotherapy and Pharmacology, 2006