A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells
- 1 June 1983
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 303 (5917), 497-501
- https://doi.org/10.1038/303497a0
Abstract
The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours.Keywords
This publication has 41 references indexed in Scilit:
- Oncogenes in solid human tumoursNature, 1982
- Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genomeCell, 1982
- Cellular Transforming GenesScience, 1982
- Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.Proceedings of the National Academy of Sciences of the United States of America, 1982
- Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras geneNature, 1982
- Form and Function of Retroviral ProvirusesScience, 1982
- Oncogenes of Spontaneous and Chemically Induced TumorsAdvances in Cancer Research, 1982
- Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomasNature, 1982
- Specific integration of REV proviruses in avian bursal lymphomasNature, 1981
- Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosisNature, 1981