Cellular Transforming Genes
- 27 August 1982
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4562), 801-806
- https://doi.org/10.1126/science.6285471
Abstract
Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.This publication has 43 references indexed in Scilit:
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