Early events governing memory CD8+ T-cell differentiation
Open Access
- 26 May 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 22 (8), 619-625
- https://doi.org/10.1093/intimm/dxq053
Abstract
Understanding the regulation of the CD8+ T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8+ T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8+ T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8+ T cells.Keywords
This publication has 92 references indexed in Scilit:
- Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T CellsImmunity, 2010
- Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell PropertiesImmunity, 2009
- Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T CellsImmunity, 2009
- Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiationVaccine, 2009
- An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and ToleranceImmunity, 2009
- In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infectionEuropean Journal of Immunology, 2008
- Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to InfectionImmunity, 2008
- AMPK Phosphorylation of Raptor Mediates a Metabolic CheckpointMolecular Cell, 2008
- Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription FactorImmunity, 2007
- Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activationSeminars in Immunology, 2007