Reduced glycemic variability and flexible graft function after islet transplantation: A case report
Open Access
- 1 November 2020
- journal article
- research article
- Published by Wiley in Journal of Diabetes Investigation
- Vol. 11 (6), 1677-1680
- https://doi.org/10.1111/jdi.13292
Abstract
To date, studies of patients with islet transplantation addressing intermittently scanned continuous glucose monitoring profile and the flexibility of the graft islet function under different doses of insulin administration, both of which reflect the real daily life of patients, are quite limited. Here, we report a case of a 46-year-old woman who received islet transplantation after kidney transplantation. The patient was followed up over a period of 2 years after initial islet transplantation. Our results show that intermittently scanned continuous glucose monitoring can be useful for monitoring the reduction of glycemic variability, and suggest the appropriate regulation of insulin secretion from graft islets during mixed-meal test by using different doses of exogenous insulin administration. Additionally, during the 2-year observational period, glucagon elevation was detected only at hypoglycemia, whereas the level was within the normal range at normoglycemia or hyperglycemia.Keywords
Funding Information
- Japan Agency for Medical Research and Development (JP16lk0201042)
This publication has 8 references indexed in Scilit:
- Long‐term outcome of islet transplantation on insulin‐dependent diabetes mellitus: An observational cohort studyJournal of Diabetes Investigation, 2019
- Long-term Effect of Islet Transplantation on Glycemic VariabilityCell Transplantation, 2018
- Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin InjectionsTransplantation, 2017
- Outcomes of Pancreatic Islet Allotransplantation Using the Edmonton Protocol at the University of ChicagoTransplantation Direct, 2016
- Islet Transplantation Using Donors After Cardiac Death: Report of the Japan Islet Transplantation RegistryTransplantation, 2010
- Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of β-Cell Function in Therapeutic Trials in Type 1 DiabetesDiabetes Care, 2008
- SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetesDiabetes Research and Clinical Practice, 2006
- Reduction of Blood Glucose Variability in Type 1 Diabetic Patients Treated By Pancreatic Islet TransplantationDiabetes Care, 2002