Long-term Effect of Islet Transplantation on Glycemic Variability
Open Access
- 30 April 2018
- journal article
- research article
- Published by SAGE Publications in Cell Transplantation
- Vol. 27 (5), 840-846
- https://doi.org/10.1177/0963689718763751
Abstract
Islet transplantation has been reported to restore normoglycemia and the overall metabolic control in type I diabetes mellitus (DM). In the most experienced centers, islet transplantation clinical outcome is similar to that of the whole pancreas transplantation. Long-term islet transplantation function remains a very interesting matter worth discussing. A progressive islet function decrease was reported, probably due to islet exhaustion. In 5 islet-transplanted patients with at least 3-yr follow-up and still insulin independent, their glycemic control was characterized by a blinded retrospective continuous glucose monitoring system (CGMS). Islet transplantation restored glycemic control and glucose variability. Data were compared with patients in the waiting list. All the parameters of glycemic variability tested had improved significantly in patients who had islet transplantation compared with those patients who were on the waiting list. In conclusion, islet transplantation is able to maintain a proper glucose control and normalize glycemic variability in selected patients. A blinded retrospective CGMS is a useful method to characterize glucose homeostasis deeply in vivo in islet-transplanted patients.Keywords
Funding Information
- Associazione Pazienti Diabetici della Provincia di Milano. (Research Grant)
This publication has 29 references indexed in Scilit:
- Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical TherapyTransplantation, 2011
- A New Method to Value Efficiency of Enzyme Blends for Pancreatic Tissue DigestionTransplantation Proceedings, 2010
- Interpretation of Continuous Glucose Monitoring Data: Glycemic Variability and Quality of Glycemic ControlDiabetes Technology & Therapeutics, 2009
- A Novel Analytical Method for Assessing Glucose Variability: Using CGMS in Type 1 Diabetes MellitusDiabetes Technology & Therapeutics, 2006
- Evaluation of a New Measure of Blood Glucose Variability in DiabetesDiabetes Care, 2006
- The Effect of Pancreatic Islet Transplantation on Progression of Diabetic Retinopathy and NeuropathyTransplantation Proceedings, 2005
- A Novel Approach to Continuous Glucose Analysis Utilizing Glycemic VariationDiabetes Technology & Therapeutics, 2005
- Metabolic effects of successful intraportal islet transplantation in insulin-dependent diabetes mellitus.JCI Insight, 1996
- Reduced Awareness of Hypoglycemia in Adults With IDDM: A prospective study of hypoglycemic frequency and associated symptomsDiabetes Care, 1995
- “J”-Index. A New Proposition of the Assessment of Current Glucose Control in Diabetic PatientsHormone and Metabolic Research, 1995