Association of the germline TP53R337H mutation with breast cancer in southern Brazil
Open Access
- 1 December 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 8 (1), 357
- https://doi.org/10.1186/1471-2407-8-357
Abstract
The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT) in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not associated with Li-Fraumeni syndrome. However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context.This publication has 32 references indexed in Scilit:
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