Characterization ofPseudomonas aeruginosaIsolates: Occurrence Rates, Antimicrobial Susceptibility Patterns, and Molecular Typing in the Global SENTRY Antimicrobial Surveillance Program, 1997–1999
Open Access
- 15 May 2001
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 32 (s2), S146-S155
- https://doi.org/10.1086/320186
Abstract
During 1997–1999, a total of 70,067 isolates (6631 Pseudomonas aeruginosa isolates) were analyzed in the SENTRY program by geographic region and body site of infection. The respiratory tract was the most common source of P. aeruginosa. P. aeruginosa isolation rates increased during the study interval. Europe was the only region to show a significant decline in β-lactam and aminoglycoside susceptibility rates. There was a reduction in the rates of susceptibility of Canadian isolates to imipenem and of Latin American isolates to meropenem. A total of 218 multidrug-resistant P. aeruginosa isolates (MDR-PSA; resistant to piperacillin, ceftazidime, imipenem, and gentamicin) were observed; MDR-PSA occurrence rates (percentages of all isolates) ranged from 8.2% (Latin America) to 0.9% (Canada). No antimicrobial inhibited >50% of MDR-PSA strains. Molecular characterization of selected, generally resistant strains was performed. Isolates showing unique ribogroups were found in Europe, Latin America, and the United States, but clonal spread was documented in several medical centers.This publication has 68 references indexed in Scilit:
- TEM-24 Produced by Four Different Species of Enterobacteriaceae , Including Providencia rettgeri , in a Single PatientAntimicrobial Agents and Chemotherapy, 1999
- β-lactamase-mediated resistance to extended spectrum cephalosporins among clinical isolates of Pseudomonas aeruginosaResearch in Microbiology, 1999
- Carbapenem-hydrolyzing metallo-beta-lactamases in Pseudomonas aeruginosa.European Journal of Clinical Microbiology & Infectious Diseases, 1999
- Control of Outbreaks Due to Organism Producing Extended-Spectrum β-LactamasesJAMA, 1999
- Nosocomial Infections With Ceftazidime-Resistant Pseudomonas aeruginosa: Risk Factors and OutcomeInfection Control & Hospital Epidemiology, 1999
- National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from October 1986–April 1998, Issued June 1998American Journal of Infection Control, 1998
- Extended-spectrum beta-lactamases in Pseudomonas aeruginosaJournal of Antimicrobial Chemotherapy, 1998
- Rapid Detection and Evaluation of Clinical Characteristics of Emerging Multiple-Drug-Resistant Gram-Negative Rods Carrying the Metallo-β-Lactamase Gene bla IMPAntimicrobial Agents and Chemotherapy, 1998
- Expression of Pseudomonas aeruginosa Multidrug Efflux Pumps MexA-MexB-OprM and MexC-MexD-OprJ in a Multidrug-Sensitive Escherichia coli StrainAntimicrobial Agents and Chemotherapy, 1998
- Acquired carbapenemasesJournal of Antimicrobial Chemotherapy, 1997