Antiproliferative Compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest
- 30 August 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 73 (9), 1559-1562
- https://doi.org/10.1021/np100430r
Abstract
Bioassay-guided fractionation of an ethanol extract of the roots of the endemic Malagasy plant Pongamiopsis pervilleana led to the isolation of the three new compounds (2′R)-4′-hydroxyemoroidocarpan (1), pongavilleanine (3), and epipervilline (4) together with two known compounds, identified as emoroidocarpan (2) and rotenolone (5). The structures of all compounds were determined by physical, chemical, and spectroscopic evidence. The stereochemistry at C-2′ of the previously reported compound emoroidocarpan was determined to be R by the observation of a negative Cotton effect at 474 nm in the CD spectrum of its osmate ester derivative. Compounds 2−5 displayed moderate antiproliferative activity against the A2780 human ovarian cancer cell line, and rotenolone also showed micromolar antiproliferative activity toward the breast cancer BT-549, prostate cancer DU 145, NSCLC NCI-H460, and colon cancer HCC-2998 cell lines.Keywords
This publication has 14 references indexed in Scilit:
- Antiproliferative Compounds of Cyphostemma greveana from a Madagascar Dry ForestChemistry & Biodiversity, 2011
- Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest,Journal of Natural Products, 2008
- A short history of SHELXActa Crystallographica Section A Foundations of Crystallography, 2007
- Cytotoxic rotenoloids from the stems of Derris trifoliataCanadian Journal of Chemistry, 2007
- Antiproliferative Xanthones of Terminalia calcicola from the Madagascar Rain ForestJournal of Natural Products, 2007
- Cytotoxic Compounds from Mundulea chapelieri from the Madagascar RainforestJournal of Natural Products, 2004
- Twenty-three flavonoids from Lonchocarpus subglaucescensPhytochemistry, 1996
- Three New Flavonoids from the Root of Tephrosia emoroides and their Antifeedant Activity against the Larvae of the Spotted Stalk Borer Chilo partellus SwinhoeInternational Journal of Pharmacognosy, 1995
- Isolation and Structural Elucidation of Potentially Insecticidal and Acaricidal Isoflavone-Type Compounds from Neorautanenia mitisJournal of Natural Products, 1987
- X-Ray Structure Determination of Neoduline C18H12O5Bulletin des Sociétés Chimiques Belges, 1986