COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission
Open Access
- 12 May 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Human Genomics
- Vol. 14 (1), 1-7
- https://doi.org/10.1186/s40246-020-00267-3
Abstract
The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV and MERS-CoV. With the number of COVID-19 cases now exceeding 2 million worldwide, it is apparent that (i) transmission of SARS-CoV-2 is very high and (ii) there are large variations in disease severity, one component of which may be genetic variability in the response to the virus. Controlling current rates of infection and combating future waves require a better understanding of the routes of exposure to SARS-CoV-2 and the underlying genomic susceptibility to this disease. In this mini-review, we highlight possible genetic determinants of COVID-19 and the contribution of aerosol exposure as a potentially important transmission route of SARS-CoV-2.Keywords
This publication has 57 references indexed in Scilit:
- Aerobiology and Its Role in the Transmission of Infectious DiseasesJournal of Pathogens, 2013
- Molecular and Microscopic Analysis of Bacteria and Viruses in Exhaled Breath Collected Using a Simple Impaction and Condensing MethodPLOS ONE, 2012
- Viral evolution and transmission effectivenessWorld Journal of Virology, 2012
- Qualitative Real-Time Schlieren and Shadowgraph Imaging of Human Exhaled Airflows: An Aid to Aerosol Infection ControlPLOS ONE, 2011
- Simple Respiratory Protection—Evaluation of the Filtration Performance of Cloth Masks and Common Fabric Materials Against 20–1000 nm Size ParticlesAnnals of Work Exposures and Health, 2010
- The effect of environmental parameters on the survival of airborne infectious agentsJournal of The Royal Society Interface, 2009
- Methods for Sampling of Airborne VirusesMicrobiology and Molecular Biology Reviews, 2008
- Professional and Home-Made Face Masks Reduce Exposure to Respiratory Infections among the General PopulationPLOS ONE, 2008
- Review of Aerosol Transmission of Influenza A VirusEmerging Infectious Diseases, 2006
- Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisThe Journal of Pathology, 2004