Role of C-Peptide in the Regulation of Microvascular Blood Flow
Open Access
- 28 July 2008
- journal article
- review article
- Published by Hindawi Limited in Experimental Diabetes Research
- Vol. 2008, 1-8
- https://doi.org/10.1155/2008/176245
Abstract
During the recent years, the role of C-peptide, released from the pancreatic beta cell, in regulating microvascular blood flow, has received increasing attention. In type 1 diabetic patients, intravenous application of C-peptide in physiological concentrations was shown to increase microvascular blood flow, and to improve microvascular endothelial function and the endothelial release of NO. C-peptide was shown to impact microvascular blood flow by several interactive pathways, like stimulatingATPase or the endothelial release of NO. There is increasing evidence, that in patients with declining beta cell function, the lack of C-peptide secretion might play a putative role in the development of microvascular blood flow abnormalities, which go beyond the effects of declining insulin secretion or increased blood glucose levels.
Keywords
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