Increased Sodium Influx into Erythrocytes in Diabetes Mellitus and Hypertension
- 1 January 1986
- journal article
- research article
- Published by Informa UK Limited in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 8 (2), 185-199
- https://doi.org/10.3109/10641968609074771
Abstract
A variety of abnormality has been reported in the cation transport systems in erythrocytes in essential hypertension. To determine the existence of similar abnormality in diabetics with hypertension, sodium (Na+) influx into erythrocytes in the presence of ouabain (measured by using 22Na+), and the Na+ and potassium (K+) content in intact erythrocytes were examined. Subjects, all of whom were Japanese, were divided into 4 groups; 23 nondiabetic, normotensive control subjects without family history of hypertension (control group), 20 patients with essential hypertension (group 1), 21 normotensive diabetics without family history of hypertension (group 2) and 15 hypertensive diabetics (group 3). Na+-K+ pump activity (measured by using 86Rb+) was studied in some of them, too. Na+ influx in group 1 was 0.451±0.111 m mol/Kg erythrocytes/h, significantly more elevated than that in the control group (0.345±0.080, p < 0.001). Na+ influx in group 2(0.435±0.094) was significantly greater than that in the control group(p < 0.005), but no significant difference was found between groups 1 and 2. Na+ influx in group 3 (0.551±0.128) was significantly higher than that in the control group (p < 0.001), in group 1(p < 0.02), or in group 2(p < 0.005). There were no significant differences in Na+-K+ pump activity, or Na+ and K+ content among the 4 groups. These findings suggested that: 1) Na+ influx into ouabain-treated erythrocytes was higher in patients with essential hypertension than in control subjects in Japanese, 2) diabetes mellitus per se might increase Na+ influx, and 3) the elevation of blood pressure in hypertensive diabetics as well as in essential hypertensives might be related to the increased Na+ influx.Keywords
This publication has 18 references indexed in Scilit:
- Abnormal Na+K+ cotransport function in a group of patients with essential hypertensionEuropean Journal of Clinical Investigation, 1983
- An improved method for measuring intracellular electrolytes m erythrocytes and the effects of cold storageClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- Normalizing effects of plasma on altered cation transport of red blood cells from essential hypertensive patients.Japanese Circulation Journal, 1983
- Racial differences in hypertension-associated red cell sodium permeabilityNature, 1982
- Assessment of red cell sodium transport in essential hypertensionBlood, 1982
- DIABETES AND HYPERTENSION IN A COMMUNITY OF OLDER ADULTSAmerican Journal of Epidemiology, 1981
- Increased Sodium-Lithium Countertransport in Red Cells of Patients with Essential HypertensionNew England Journal of Medicine, 1980
- Laboratory Distinction between Essential and Secondary Hypertension by Measurement of Erythrocyte Cation FluxesNew England Journal of Medicine, 1980
- Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose IntoleranceDiabetes, 1979
- Some aspects of hypertension in diabetes mellitusPublished by American Medical Association (AMA) ,1967