Respiratory microbiota and lower respiratory tract disease
Open Access
- 3 July 2017
- journal article
- research article
- Published by Taylor & Francis Ltd in Expert Review of Anti-infective Therapy
- Vol. 15 (7), 703-711
- https://doi.org/10.1080/14787210.2017.1349609
Abstract
Introduction: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes. Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions. Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.Keywords
Funding Information
- Fundação para a Ciência e a Tecnologia (SFRH/BD/70110/2010)
- Plan Nacional I+D+i (PI16/00174)
- European Regional Development Fund (FEDER)
- Instituto de Salud Carlos III- Subdirección General de Evaluación y Fomento de la Investigación Sanitaria (PI16/00174)
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