Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
- 27 April 2012
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 336 (6080), 489-493
- https://doi.org/10.1126/science.1219328
Abstract
Exposure to microbes during early childhood is associated with protection from immune-mediated diseases such as inflammatory bowel disease (IBD) and asthma. Here, we show that in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen-free mice. This was associated with increased intestinal and pulmonary expression of the chemokine ligand CXCL16, which was associated with increased mucosal iNKT cells. Colonization of neonatal—but not adult—GF mice with a conventional microbiota protected the animals from mucosal iNKT accumulation and related pathology. These results indicate that age-sensitive contact with commensal microbes is critical for establishing mucosal iNKT cell tolerance to later environmental exposures.Keywords
This publication has 37 references indexed in Scilit:
- Preschool wheeze – impact of early fish introduction and neonatal antibioticsActa Paediatrica, 2011
- Invariant NKT cells are required for airway inflammation induced by environmental antigensThe Journal of Experimental Medicine, 2011
- Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophagesJCI Insight, 2011
- Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosineNature Biotechnology, 2011
- CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genesProceedings of the National Academy of Sciences of the United States of America, 2010
- Expression and regulation of the chemokine CXCL16 in Crohnʼs disease and models of intestinal inflammationInflammatory Bowel Diseases, 2010
- Commensal Microbiota and CD8+ T Cells Shape the Formation of Invariant NKT CellsThe Journal of Immunology, 2009
- Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43Nature, 2009
- Microbes in Gastrointestinal Health and DiseaseGastroenterology, 2009
- THE CHEMOKINE CXCL16 IS HIGHLY AND CONSTITUTIVELY EXPRESSED BY HUMAN BRONCHIAL EPITHELIAL CELLSExperimental Lung Research, 2009