Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow
Top Cited Papers
- 2 December 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 62 (4), 2049-2059
- https://doi.org/10.1021/acs.jmedchem.8b01682
Abstract
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by indocyanine green structure, a series of polymethine dyes with both absorption and emission in NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in NIR-IIa (1300-1400 nm) sub-window under 1064 nm excitation with that in NIR-II window under 808 nm excitation. The signal-background ratio (SBR) and tumor to normal tissue ratio (T/NT) achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.Keywords
Funding Information
- National Cancer Institute (P50 CA114747)
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Jiangsu Province (BK20160387)
- Office of Science
- U.S. Department of Energy (DE-SC0008397)
- China Scholarship Council
- National Natural Science Foundation of China (81573383, 81773674, 21390402)
- Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals
- Shenzhen Municipality (JCYJ20170303170809222)
- Scientifc and Technologic Council of Suzhou (SYG201521)
- Hubei Province (2017CFA024, 2017CFB711, 2016ACA126)
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