Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii
- 2 December 2017
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Infectious Diseases
- Vol. 4 (3), 315-324
- https://doi.org/10.1021/acsinfecdis.7b00183
Abstract
In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.Keywords
Funding Information
- Vanderbilt University
- U.S. Department of Veterans Affairs (CDA-2 1IK2BX001701)
- Department of Pediatrics, Vanderbilt University Medical Center
- Institute of Chemical Biology, Vanderbilt University
This publication has 52 references indexed in Scilit:
- New antibiotics for bad bugs: where are we?Annals of Clinical Microbiology and Antimicrobials, 2013
- Human Milk Oligosaccharides Promote the Growth of StaphylococciApplied and Environmental Microbiology, 2012
- Individuals with Le(a+b−) Blood Group Have Increased Susceptibility to Symptomatic Vibrio cholerae O1 InfectionPLoS Neglected Tropical Diseases, 2011
- Multiresistant Acinetobacter baumannii infections: epidemiology and managementCurrent Opinion in Infectious Diseases, 2010
- Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970–2010: a systematic analysis of progress towards Millennium Development Goal 4The Lancet, 2010
- Staphylococcuscolonization of the skin and antimicrobial peptidesExpert Review of Dermatology, 2010
- Specific Involvement of Pilus Type 2a in Biofilm Formation in Group B StreptococcusPLOS ONE, 2010
- Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of AmericaClinical Infectious Diseases, 2009
- The Catabolite Control Protein CcpA Binds to P mga and Influences Expression of the Virulence Regulator Mga in the Group A StreptococcusJournal of Bacteriology, 2007
- Combination of Tigecycline and N -Acetylcysteine Reduces Biofilm-Embedded Bacteria on Vascular CathetersAntimicrobial Agents and Chemotherapy, 2007